Department of Neurology

Select Publications

Prater KE, Green KJ, Mamde S, Sun W, Cochoit A, Smith CL, Chiou KL, Heath L, Rose SE, Wiley J, Keene CD, Kwon RY, Snyder-Mackler N, Blue EE, Logsdon B, Young JE, Shojaie A, Garden GA and Jayadev S “Human microglia show unique transcriptional change in Alzheimer’s disease”.  Nat Aging. 2023 Jul;3(7):894-907. doi: 10.1038/s43587-023-00424-y. Epub 2023 May 29.

Knox KM, Beckman M, Smith CL, Jayadev S, Barker-Haliski M.” Chronic seizures induce sex-specific cognitive deficits with loss of presenilin 2 function” Exp Neurol. 2023 Mar;361:114321. doi: 10.1016/j.expneurol.2023.114321

Fazeli E, Child DD, Bucks SA, Stovarsky M, Edwards G, Yu CE, Latimer C, Kitago Y, Bird T, Andersen OM, Jayadev S, Young JE “A familial missense variant in the AD gene SORL1 impairs its maturation and endosomal sorting” bioRxiv  2023 Jul 5;2023.07.01.547348. doi: 10.1101/2023.07.01.547348.

Course MM, Gudsnuk K, Keene CD, Bird TD, Jayadev S, Valdmanis PN. “Aberrant splicing of PSEN2, but not PSEN1, in individuals with sporadic Alzheimer’s disease”. Brain. 2023 Feb 13;146(2):507-518

Smukowski SN, Maioli H, Latimer CS, Bird TD, Jayadev S, Valdmanis PN. ”Progress in Amyotrophic Lateral Sclerosis Gene Discovery: Reflecting on Classic Approaches and Leveraging Emerging Technologies.”. Neurol Genet. 2022 Apr 27;8(3):e669

Davis M, Wheelock V, Talman L, Latimer C, Vicars B, Lin A, Jayadev S, Bird T. “Subdural Hematoma as a Serious Complication of Huntington’s Disease: An Observational Study.” J Huntingtons Dis. 2021;10(3):385-390. doi: 10.3233/JHD-210478

Vicars BG, Liu AB, Holt S, Jayadev S, Bird T, Yang CC. “High Frequency of Concomitant Bladder, Bowel, and Sexual Symptoms in Huntington’s Disease: A Self-Reported Questionnaire Study.” J Pers Med. 2021 Jul 25;11(8):714. doi: 10.3390/jpm11080714

Prater KE, Latimer CS, Jayadev S. “Glial TDP-43 and TDP-43 induced glial pathology, focus on neurodegenerative proteinopathy syndromes.” Glia. 2022 Feb;70(2):239-2 55. doi: 10.1002/glia.24096. Epub 2021 Sep 24

Rolf B, Blue EE, Bucks S, Dorschner MO, Jayadev S. “Genetic counseling for early onset and familial dementia: Patient perspectives on exome sequencing”.  J Genet Couns. 2021 Jan 3. doi: 10.1002/jgc4.1379.

Knupp A, Mishra S, Martinez R, Braggin JE, Szabo M, Kinoshita C, Hailey DW, Small SA, Jayadev S, Young JE.  “Depletion of the AD Risk Gene SORL1 Selectively Impairs Neuronal Endosomal Traffic Independent of Amyloidogenic APP Processing”. Cell Rep. 2020 Jun 2;31(9):107719. doi: 10.1016/j.celrep.2020.107719

Fung S, Smith CL, Prater KE, Case A, Green K, Osnis L, Winston C, Kinoshita Y, Sopher B, Morrison RS, Garden GA, Jayadev S. “Early-Onset Familial Alzheimer Disease Variant PSEN2 N141I Heterozygosity is Associated with Altered Microglia Phenotype.” J Alzheimers Dis. 2020;77(2):675-688. doi: 10.3233/JAD-200492.

Yu CE, Chen S, Jayadev S, Bird T. “Lack of APOE Christchurch variant in five age of onset outliers with PSEN1, PSEN2 Alzheimer’s disease and MAPT frontotemporal dementia”. J Neurol Sci. 2020 Nov 15;418:117143. doi: 10.1016/j.jns.2020.117143. Epub 2020 Sep 18

Mukherjee S, Preuss C, Jayadev S, Garden GA, Greenwood AK, Sieberts SK, De Jager P, Ertekin-Taner N, Carter GW, Mangravite LM, Logsdon BA. “Molecular estimation of neurodegeneration pseudotime in older brains”.. Nat Commun. 2020 Nov 13;11(1):5781. doi: 10.1038/s41467-020-19622-y

Beckman M, Knox K, Koneval Z, Smith C, Jayadev S, Barker-Haliski M.”Loss of presenilin 2 age-dependently alters susceptibility to acute seizures and kindling acquisition”. Neurobiol Dis. 2020 Mar;136:104719. doi: 10.1016/j.nbd.2019.104719

Braggin JE, Bucks SA, Course MM, Smith CL, Sopher B, Osnis L, Shuey KD, Domoto-Reilly K, Caso C, Kinoshita C, Scherpelz KP, Cross CC, Grabowski T, Nik SH, Newman M, Garden GA, Leverenz JB, Tsuang D, Latimer C, Gonzalez-Cuyar LF, Keene CD, Morrison RS, Roads K, Wijsman EM, Dorschner MO, Lardelli M, Young JE, Valdmanis PN, Bird TD, Jayadev S. “Alternative splicing in a presenilin 2 variant associated with Alzheimer disease”. Annals of Clinical and Translational Neurology. 2019 Apr;6(4):762-777

Pearl JR, Heath LM, Bergey DE, Kelly JP, Smith C, Laurino MY, Weiss A, Price ND, LaSpada A, Bird TD, Jayadev S. “Enhanced retinal responses in Huntington’s disease patients”. J Huntington Dis.  2017;6(3):237-247. doi: 10.3233/JHD-170255

Amos PJ, Fung S, Case A, Kifelew J, Osnis L, Smith CL, Green K, Naydenov A, Aloi M, Hubbard JJ, Ramakrishnan A, Garden GA, Jayadev S. “Modulation of Hematopoietic Lineage Specification Impacts TREM2 Expression in Microglia-Like Cells Derived From Human Stem Cells.  ASN Neuro. 2017 Jul-Aug;9(4):1759091417716610

Jayadev S, Case A, Alajajian B, Eastman AJ, Möller T, Garden GA “Presenilin 2 influences miR146 level and activity in microglia” J Neurochem. 2013 doi: 10.1111/jnc.12400

Jayadev S, Nesser N, Seaburg LA, Lee R, Murphy SP, Hopkins S, Case A, Uo T, Morrison RS, Meyers S, Garden GA “The Transcription Factor p53 Influences Microglia Activation Phenotype”. Glia. 2011 Oct;59(10):1402-13

Jayadev S, Nochlin D, Poorkaj P, Steinbart EJ, Mastrianni JA, Montine TJ, Ghetti B, Schellenberg GD, Bird TD and Leverenz JB, “Familial prion disease with alzheimer disease-like tau pathology and clinical phenotype”. Ann Neurol. 2011 April; 69 (4):712-20

Jayadev S, Leverenz JB, Steinbart EJ, Stahl J, Klunk W, Bird TD.  “Alzheimer disease phenotypes and genotypes with mutations in presenilin 2”.  2010 Brain. Apr;133(Pt 4):1143-54

Jayadev S, Steinbart EJ, Chi YY, Kukull WA, Jagust WJ, Schellenberg G, Bird TD.  Conjugal Alzheimer Disease:  Risk in Children When Both Parents Have Alzheimer Disease. Arch of Neurology.  2008 Mar;65(3):373-8