Department of Neurology

Selected Publications

Recent original research

Our description of “pyramidal-like principal” neurons that have a reversed HCN channel gradient compared to CA1 hippocampal pyramidal neurons made the cover of J. Physiol. (Bullis et al., 2007).

Poolos NP, Roth MK, Bullis JB (2006). Modulation of h-channels in hippocampal pyramidal neurons by p38 MAPK. J. Neurosci. 26:7995-8003.
Commentary in J. Neurosci.

Bullis JB,  Jones TD, Poolos NP (2007). Reversed somatodendritic Ih gradient in a class of hippocampal neurons with pyramidal morphology, J. Physiol. 579:431-443.

Jung S, Jones TD, Lugo Jr. JN, Sheerin AH, Miller JW, D’Ambrosio R, Anderson AE, Poolos NP (2007). Progressive dendritic HCN channelopathy during epileptogenesis in the rat pilocarpine model of epilepsy. J. Neurosci. 27:13012-13021.
Commentary in Epilepsy Currents.

Jung S, Bullis JB, Lau IH, Jones TD, Warner LN, Poolos NP (2010). Downregulation of dendritic HCN channel gating in epilepsy is mediated by altered phosphorylation signalling, J. Neurosci., 30:6678-6688.

Jung S, Warner LN, Pitsch J, Becker AJ, Poolos NP (2011). Rapid loss of dendritic HCN channel expression in hippocampal pyramidal neurons following status epilepticus. J. Neurosci. 31:14291-14295. Commentary in Epilepsy Currents.

Poolos NP, Warner LN, Humphreys SZ, Williams S (2012). Comparative efficacy of combination drug therapy in refractory epilepsy. Neurology 78:62-68.

UW press release. Epilepsy Foundation commentary. Brief UW interview (.mp3).

Williams AD, Jung S, Poolos NP (2015). Protein kinase C bidirectionally modulates Ih and hyperpolarization-activated cyclic nucleotide-gated (HCN) channel surface expression in hippocampal pyramidal neurons. J. Physiol. 593: 2779-2792.

Poolos NP, Castagna CE, Williams S, Miller AB, Story TJ (2017). Association between antiepileptic drug dose and long-term response in patients with refractory epilepsy. Epilepsy Behav., 69:59-68.

Tai  TY, Warner LN, Jones TD, Jung S, Concepcion FA, Skyrud DW, Fender J, Liu Y, Williams AD, Neumaier JF, D’Ambrosio R, Poolos NP (2017). Antiepileptic action of c-Jun N-terminal kinase (JNK) inhibition in an animal model of temporal lobe epilepsy. Neuroscience 349:35-47.

Recent reviews and book chapters

Poolos NP (2009). Acquired ion channel dysfunction in epilepsy. In: Schwartzkroin PA. Encyclopedia of Basic Epilepsy Research, Elsevier.

Poolos NP (2012). Hyperpolarization-activated, cyclic nucleotide-gated (HCN) ion channelopathy in epilepsy. In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds. Jasper’s Basic Mechanisms of the Epilepsies, 4th Ed., Oxford University Press.

Poolos NP 2014. Optimizing antiepileptic drug therapy in refractory epilepsy. In: Epilepsy, Miller JW, Goodkin HP, eds. Wiley Blackwell.

Brennan GP, Baram TZ, Poolos NP (2016). Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in epilepsy. In: Epilepsy: Biology of a Spectrum Disorder, Holmes GL, Noebels JL, eds. Cold Spring Harbor Perspectives in Medicine.

Johnston D, Frick A, Poolos NP (2016). Dendrites and disease. In: Dendrites, 3rd ed. Stuart G, Spruston N, Hausser M, eds. Oxford University Press.